Detection of Statin Cytotoxicity Is Increased in Cells Expressing the OATP1B1 Transporter
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چکیده
منابع مشابه
Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter.
Cytotoxicity of a compound is determined by the intracellular concentration mediated both by passive permeability and active uptake through drug transporters. However, the major liver uptake transporters were either absent or expressed at significantly lower levels in human liver cell lines than in human liver. When comparing cytotoxicity of five statins, the organic anion transporting polypept...
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Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For montelukast, no significant difference in cell uptake between HEK-OATP2B1 and empty vector cell ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2013
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kft085